⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149626 | 0.84 | HRH3 (0.30) | — | |
| SCHEMBL20148696 | 0.84 | — | — | |
| SCHEMBL20071349 | 0.74 | ALOX15 (0.49) | — | |
| SCHEMBL20154485 | 0.73 | RET (0.40) | — | |
| SCHEMBL20154486 | 0.70 | RET (0.42) | — | |
| SCHEMBL22031280 | 0.69 | RET (0.37) | — | |
| SCHEMBL22031271 | 0.68 | RET (0.37) | — | |
| SCHEMBL22811895 | 0.68 | RET (0.37) | — | |
| SCHEMBL20071341 | 0.68 | RET (0.39) | — | |
| SCHEMBL22031240 | 0.67 | RET (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |