Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23126231 | 0.85 | ALOX15 (0.50) | ALOX15RETCCR5KAT2BTAAR1 | |
| SCHEMBL20148678 | 0.84 | ALOX15 (0.45) | ALOX15RETCCR5KAT2BTAAR1 | |
| SCHEMBL20149621 | 0.84 | ALOX15 (0.45) | ALOX15RETCCR5KAT2BTAAR1 | |
| SCHEMBL18325471 | 0.80 | ALOX15 (0.58) | ALOX15CCR5KAT2BTAAR1PARP1 | |
| SCHEMBL18325491 | 0.76 | ALOX15 (0.53) | ALOX15CCR5KAT2BTAAR1OPRM1 | |
| SCHEMBL20071344 | 0.74 | — | — | |
| SCHEMBL22030578 | 0.73 | RET (0.34) | RET | |
| SCHEMBL18390924 | 0.69 | KMT2A (0.44) | RETOPRM1ALDH1A1 | |
| SCHEMBL20070534 | 0.69 | VNN1 (0.41) | RETPARP1TDP1 | |
| SCHEMBL2295430 | 0.67 | ALOX15 (0.65) | ALOX15KAT2BTAAR1OPRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |