Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DNM1L | O00429 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148689 | 0.85 | RET (0.43) | RETKMT2AMEN1PDE2AALDH1A1 | |
| SCHEMBL20149623 | 0.85 | RET (0.40) | RETKMT2AMEN1PDE2AALDH1A1 | |
| SCHEMBL20154603 | 0.82 | RET (0.40) | RETKMT2AMEN1PDE2AALDH1A1 | |
| SCHEMBL22031279 | 0.78 | RET (0.42) | RETKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL14367258 | 0.74 | KMT2A (0.47) | KMT2AMEN1PDE2AALDH1A1MAPK1 | |
| SCHEMBL22031262 | 0.69 | RET (0.42) | RET | |
| SCHEMBL19014516 | 0.68 | JAK2 (0.43) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL22030578 | 0.66 | RET (0.34) | RETLMNA | |
| SCHEMBL13333198 | 0.66 | FDPS (0.38) | KMT2AMEN1PDE2AALDH1A1MAPK1 | |
| SCHEMBL22031280 | 0.66 | RET (0.37) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |