Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154516 | 0.86 | KMT2A (0.50) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL12296593 | 0.84 | KMT2A (0.54) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL1919732 | 0.83 | KMT2A (0.53) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL20148747 | 0.82 | GAA (0.60) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL20626519 | 0.82 | KDM2B (0.51) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL20160470 | 0.80 | GAA (0.47) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL2438590 | 0.80 | KMT2A (0.50) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL1920025 | 0.80 | KMT2A (0.50) | KMT2APKMHTTALDH1A1POLB | |
| SCHEMBL20070949 | 0.76 | RET (0.46) | KMT2AHTTALDH1A1MEN1GAA | |
| SCHEMBL19457355 | 0.74 | PKM (0.73) | KMT2APKMHTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |