Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247237 | 0.92 | PLA2G1B (0.39) | TSHRPLA2G1BPLA2G2ALMNA | |
| Alcohol SCHEMBL2126840 | 0.90 | TSHR (0.42) | TSHRPLA2G1BPLA2G2ALMNAALDH1A1 | |
| Isopropyl Alcohol SCHEMBL2245070 | 0.86 | TSHR (0.45) | TSHRLMNAALDH1A1CA1 | |
| Acetic Acid SCHEMBL1244963 | 0.83 | CHRM1 (0.41) | TSHRPLA2G1BPLA2G2AALDH1A1CA12 | |
| Isopropyl Alcohol SCHEMBL3893557 | 0.83 | ALDH1A1 (0.46) | TSHRLMNAALDH1A1L3MBTL1 | |
| Isopropyl Alcohol SCHEMBL3610389 | 0.80 | TSHR (0.33) | TSHR | |
| Isopropyl Alcohol SCHEMBL18984957 | 0.80 | ALDH1A1 (0.43) | TSHRLMNAALDH1A1L3MBTL1 | |
| Isopropyl Alcohol SCHEMBL28231979 | 0.80 | ALDH1A1 (0.43) | TSHRLMNAALDH1A1L3MBTL1 | |
| Butyric Acid SCHEMBL2140387 | 0.78 | HDAC1 (0.52) | TSHRALDH1A1 | |
| Hexane SCHEMBL1545339 | 0.78 | PLA2G1B (0.43) | TSHRPLA2G1BPLA2G2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964616-B2 | 6-chloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}-2-[(3S)-3-hydroxypyrrolidin-1-yl]quinoline-5-carboxamide; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2011-06-21 | — | — | US | disclosed |
| US-20080234319-A1 | 6-chloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}-2-[(3S)-3-hydroxypyrrolidin-1-yl]quinoline-5-carboxamide; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234319-A1 | 6-chloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}-2-[(3S)-3-hydroxypyrrolidin-1-yl]quinoline-5-carboxamide; rheumatoid arthritis | CNKSR1, HRH4, HRH1 | TSHR 1017/4885PLA2G1B 3182/4885PLA2G2A 2892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.