Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL1509189 | 0.89 | HDAC1 (0.65) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Acetic Acid SCHEMBL1244963 | 0.85 | CHRM1 (0.41) | HDAC1HDAC2HDAC8ALDH1A1TDP1 | |
| Butyric Acid SCHEMBL834319 | 0.85 | FFAR3 (0.72) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Butyric Acid SCHEMBL8517702 | 0.83 | FFAR3 (0.68) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Butyric Acid SCHEMBL5477656 | 0.83 | FFAR3 (0.68) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Butyric Acid SCHEMBL8712901 | 0.81 | FFAR3 (0.59) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Butyric Acid SCHEMBL3414262 | 0.81 | FFAR3 (0.59) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Butyric Acid SCHEMBL9486329 | 0.81 | FFAR3 (0.65) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Butyric Acid SCHEMBL10947590 | 0.81 | FFAR3 (0.65) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Butyric Acid SCHEMBL5904081 | 0.81 | FFAR3 (0.65) | HDAC1HDAC2FFAR3HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629271-B2 | Compounds | ASTRAZENECA AB (GB) | 2014-01-14 | — | — | US | disclosed |
| US-20120322788-A1 | Compouds | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-12-20 | — | — | US | disclosed |
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| EP-2242759-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2010-10-27 | — | — | EP | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| WO-2009098448-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322788-A1 | Compouds | PKD1, SBDS, ABCB11 | HDAC1 78/4885HDAC2 185/4885FFAR3 2668/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | HDAC1 390/4885HDAC2 407/4885FFAR3 1557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.