Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21306749 | 0.88 | SCN9A (0.40) | KDM1ASCN9A | |
| Hydrochloric Acid SCHEMBL21294916 | 0.87 | SCN9A (0.39) | HTR2CHTR2AHTR2BHRH3KDM1A | |
| SCHEMBL28491550 | 0.83 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3KDM1A | |
| SCHEMBL20063858 | 0.83 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3KDM1A | |
| SCHEMBL20063859 | 0.83 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3KDM1A | |
| Hydrochloric Acid SCHEMBL21294710 | 0.82 | HTR2C (0.50) | HTR2CHTR2AHTR2BHRH3KDM1A | |
| Hydrochloric Acid SCHEMBL28517839 | 0.82 | HTR2C (0.50) | HTR2CHTR2AHTR2BHRH3KDM1A | |
| SCHEMBL20063877 | 0.81 | MAP1LC3B (0.36) | HTR2CHTR2AHTR2BHRH3MAOB | |
| SCHEMBL20063902 | 0.80 | AKR1C3 (0.46) | HTR2CMAOBKDM1AMAOARCOR1 | |
| SCHEMBL20063481 | 0.77 | SCN9A (0.43) | HTR2CHTR2AHTR2BHRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115354-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| US-10457654-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115354-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | NPY5R, REN, F12 | HTR2C 1243/4885HTR2A 2222/4885HTR2B 1239/4885 |
| US-10457654-B2 | Therapeutic compounds and methods of use thereof | NPY5R, REN, F12 | HTR2C 1243/4885HTR2A 2222/4885HTR2B 1239/4885 |
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | NPY5R, REN, F12 | HTR2C 1184/4885HTR2A 2099/4885HTR2B 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.