Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064048 | 0.83 | HDAC6 (0.46) | PLK1MAPK14HDAC6HDAC8HDAC2 | |
| SCHEMBL25497533 | 0.82 | POLB (0.44) | EPHX2NR1H4TSHRSMN1; SMN2 | |
| SCHEMBL25497536 | 0.81 | ALDH1A1 (0.48) | HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL13870617 | 0.79 | ADCY8 (0.50) | HDAC6HDAC8HDAC2PLAUHPGD | |
| SCHEMBL12505804 | 0.76 | PLK1 (0.58) | PLK1HDAC6HDAC8HDAC2EPHX2 | |
| SCHEMBL18781295 | 0.75 | PLK1 (0.56) | PLK1HDAC6HDAC8HDAC2PLAU | |
| SCHEMBL4141704 | 0.74 | KMT2A (0.56) | HDAC6HDAC8HDAC2NR1H4PLAU | |
| SCHEMBL15158511 | 0.73 | PLAU (0.47) | PLK1MAPK14HDAC6HDAC8HDAC2 | |
| SCHEMBL12068769 | 0.73 | PTGS1 (0.49) | MAPK14LCKEPHX2NR1H4HPGD | |
| SCHEMBL22745905 | 0.73 | SLC6A2 (0.49) | PLK1HDAC6HDAC8HDAC2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2019-07-30 | — | — | US | disclosed |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | BRANDEIS UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | MAP3K20, MAP3K19, MAP3K5 | PLK1 49/4885MAPK14 132/4885LCK 256/4885 |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K5 | PLK1 49/4885MAPK14 132/4885LCK 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.