ADCY8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1919194	0.53	7/20
SCHEMBL2653753	0.51	7/20
SCHEMBL2653428	0.58	6/20
SCHEMBL2653879	0.57	6/20
SCHEMBL1765784	0.55	5/20
SCHEMBL2654058	0.54	5/20
SCHEMBL1765631	0.54	5/20
SCHEMBL1765707	0.45	5/20
SCHEMBL1765425	0.44	5/20
SCHEMBL1033441	0.43	5/20
SCHEMBL1033442	0.43	5/20
SCHEMBL1765098	0.67	4/20
SCHEMBL1765737	0.65	4/20
SCHEMBL2653535	0.55	4/20
SCHEMBL1765604	0.53	4/20
SCHEMBL1919147	0.52	4/20
SCHEMBL2651542	0.50	4/20
SCHEMBL1765233	0.48	4/20
SCHEMBL2651836	0.42	4/20
SCHEMBL1765155	0.67	3/20

Clinical trials — most relevant to ADCY8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phenoxybenzamine Versus Doxazosin in PCC Patients	PHASE4	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
The Effects of Tailored Judo Training and Nutritional Counseling on Physical Fitness and Body Composition in Children With Autism: A Study Including Blood Morphology and Genetic Analysis	nan	COMPLETED
PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
The Effects of Capsinoids on Brown Adipose Tissue Activation in Obesity	nan	COMPLETED
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing	nan	UNKNOWN
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Seven Year Update of Macular Degeneration Patients	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADCY8 binder may also engage these)

Protein	Name	Similarity
P40146	—	1.000	P40146 →
P97490	—	1.000	P97490 →
P32870	—	1.000	P32870 →
Q80TL1	—	0.998	Q80TL1 →
ADCY2	Adenylate cyclase type 2	0.997	landscape →
ADCY3	Adenylate cyclase type 3	0.996	landscape →
P26769	—	0.995	P26769 →
Q9DGG6	—	0.994	Q9DGG6 →
P98999	—	0.994	P98999 →
P30804	—	0.993	P30804 →
P51829	—	0.993	P51829 →
ADCY7	Adenylate cyclase type 7 (EC 4.6.1.1) (ATP py	0.993	landscape →
Q29450	—	0.991	Q29450 →
ADCY6	Adenylate cyclase type 6 (EC 4.6.1.1) (ATP py	0.991	landscape →
Q91WF3	—	0.991	Q91WF3 →
P51830	—	0.990	P51830 →
P21932	—	0.990	P21932 →
Q8VHH7	—	0.990	Q8VHH7 →
Q9VW60	—	0.989	Q9VW60 →
ADCY9	Adenylate cyclase type 9	0.989	landscape →
Q01341	—	0.988	Q01341 →
Q6NZ21	—	0.988	Q6NZ21 →
TRPV1	Transient receptor potential cation channel subfamily V member 1	0.988	landscape →
I2HAA0	—	0.988	I2HAA0 →
P40144	—	0.988	P40144 →
Q38998	—	0.988	Q38998 →
ADCY4	Adenylate cyclase type 4 (EC 4.6.1.1) (ATP py	0.988	landscape →
Q5M7Z0	—	0.988	Q5M7Z0 →
Q03343	—	0.987	Q03343 →
Q6ZPS6	—	0.987	Q6ZPS6 →