Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | S100B | P04271 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073324 | 0.97 | AR (0.39) | ARALDH1A1MAPK1NPC1GALR3 | |
| SCHEMBL16039819 | 0.79 | ALDH1A1 (0.44) | ARALDH1A1MAPK1NPC1GALR3 | |
| SCHEMBL20073768 | 0.76 | HSD17B10 (0.40) | ALDH1A1NPC1TP53RAB9AL3MBTL1 | |
| SCHEMBL23708853 | 0.74 | KDM4E (0.51) | ARALDH1A1MAPK1NPC1TP53 | |
| SCHEMBL20073529 | 0.74 | TYK2 (0.42) | — | |
| SCHEMBL30307674 | 0.70 | KDM4E (0.47) | ARALDH1A1MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL21722473 | 0.70 | KDM4E (0.47) | ARALDH1A1MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2084707 | 0.69 | KCNMA1 (0.48) | ARALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL15971825 | 0.68 | AR (0.40) | ARALDH1A1MAPK1NPC1TP53 | |
| SCHEMBL15986781 | 0.68 | AR (0.40) | ARALDH1A1MAPK1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848370-A2 | TYK2 INHIBITORS AND USES THEREOF | Nimbus Lakshmi, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |
| WO-2018071794-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2018-04-19 | — | — | WO | disclosed |