SCHEMBL20074052

SCHEMBL20074052

COc1ccc(NC2=C(Cl)C(=O)C(Nc3ccc(OC)cc3)=C(Cl)C2=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 12/20 0.59
RAB9A P51151 6/20 0.59
MAPK1 P28482 5/20 0.59
KDM4E B2RXH2 4/20 0.59
GAA P10253 4/20 0.59
NPC1 O15118 4/20 0.59
L3MBTL1 Q9Y468 3/20 0.59
TDP1 Q9NUW8 2/20 0.59
THRB P10828 2/20 0.59
NPSR1 Q6W5P4 2/20 0.59
RECQL P46063 1/20 0.59
SMN1; SMN2 Q16637 6/20 0.56
HTT P42858 5/20 0.56
ALDH1A1 P00352 5/20 0.56
LMNA P02545 3/20 0.56
NSD2 O96028 1/20 0.56
POLB P06746 1/20 0.56
HPGD P15428 1/20 0.56
MEN1 O00255 7/20 0.51
KMT2A Q03164 7/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12283051 0.87 MAPT (0.72) MAPTRAB9AMAPK1KDM4EGAA
SCHEMBL2243450 0.77 ALDH1A1 (0.64) MAPTRAB9AMAPK1KDM4EGAA
SCHEMBL12352055 0.77 MAPT (0.58) MAPTRAB9AMAPK1KDM4EGAA
SCHEMBL20971703 0.77 ALDH1A1 (0.64) MAPTRAB9AMAPK1KDM4EGAA
Chloranil SCHEMBL11359754 0.77 CA1 (0.58) MAPTRAB9AMAPK1KDM4ETDP1
SCHEMBL39057 0.76 MAPT (1.00) MAPTRAB9AMAPK1KDM4EGAA
SCHEMBL1459772 0.76 MAPT (1.00) MAPTRAB9AMAPK1KDM4EGAA
SCHEMBL9629628 0.75 MAPT (0.77) MAPTRAB9AMAPK1KDM4EGAA
SCHEMBL10354357 0.75 ALDH1A1 (0.65) MAPTRAB9AL3MBTL1TDP1NPSR1
SCHEMBL13417403 0.74 MAPT (0.50) MAPTRAB9AMAPK1KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10745613-B2 Near-IR absorptive compounds and devices incorporating the same GENTEX CORPORATION (US) 2020-08-18 US disclosed
US-20180105738-A1 NEAR-IR ABSORPTIVE COMPOUNDS AND DEVICES INCORPORATING THE SAME GENTEX CORP (US) 2018-04-19 US disclosed