Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.55 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31676990 | 1.00 | KDM5B (0.55) | KDM5BKIF11PIK3CDMETAP2LRRK2 | |
| SCHEMBL20074250 | 0.91 | KDM5B (0.53) | KDM5BKIF11PIK3CDTLR9TLR8 | |
| SCHEMBL31676991 | 0.91 | KDM5B (0.53) | KDM5BKIF11PIK3CDTLR9TLR8 | |
| SCHEMBL20074325 | 0.89 | KDM5B (0.52) | KDM5BKIF11TLR9TLR8TLR7 | |
| SCHEMBL20074112 | 0.82 | TSHR (0.39) | KDM5BPIK3CDBRD4CREBBPTLR9 | |
| SCHEMBL20074310 | 0.81 | KDM5B (0.49) | KDM5BKIF11TLR9TLR8TLR7 | |
| SCHEMBL20074117 | 0.81 | KDM5B (0.55) | KDM5BBRD4CREBBPTLR9TLR8 | |
| SCHEMBL20074314 | 0.81 | KDM5B (0.55) | KDM5BMETAP2 | |
| SCHEMBL31676984 | 0.81 | KDM5B (0.55) | KDM5BMETAP2 | |
| SCHEMBL20074255 | 0.80 | KDM5B (0.50) | KDM5BKIF11TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975084-B2 | KDM5 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200048258-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071283-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048258-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | KDM5B 2/4885KIF11 414/4885PIK3CD 1245/4885 |
| US-10975084-B2 | KDM5 inhibitors | KDM5A, KDM5B, KDM5C | KDM5B 2/4885KIF11 414/4885PIK3CD 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.