Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.49 |
| ▸ | KDR | P35968 | 11/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20074583 | 0.92 | TGFBR1 (0.50) | TGFBR1KDRMAPK14RIPK2 | |
| SCHEMBL21277823 | 0.82 | TGFBR1 (0.57) | TGFBR1KDRMAPK14 | |
| SCHEMBL21278024 | 0.80 | TGFBR1 (0.75) | TGFBR1KDRMAPK14 | |
| SCHEMBL21277863 | 0.80 | TGFBR1 (0.75) | TGFBR1KDRMAPK14 | |
| SCHEMBL20074514 | 0.80 | TGFBR1 (0.75) | TGFBR1KDRMAPK14 | |
| SCHEMBL21277995 | 0.77 | TGFBR1 (0.57) | TGFBR1KDRMAPK14 | |
| SCHEMBL20074658 | 0.77 | TGFBR1 (0.68) | TGFBR1KDRMAPK14 | |
| SCHEMBL20074539 | 0.76 | TGFBR1 (0.65) | TGFBR1KDRMAPK14RIPK2 | |
| SCHEMBL20074516 | 0.75 | TGFBR1 (0.55) | TGFBR1KDRMAPK14 | |
| SCHEMBL20074454 | 0.74 | TGFBR1 (0.58) | TGFBR1KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068759-A1 | FIVE-MEMBERED HETEROARYL RING BRIDGED RING DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2018-04-19 | — | — | WO | disclosed |