Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | HAVCR2 | Q8TDQ0 | 4/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM4B | O94953 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076008 | 0.78 | KDM4E (0.46) | KDM5BHAVCR2HSD17B10KMT2AKDM4E | |
| SCHEMBL20074184 | 0.78 | KDM5B (0.39) | KDM5BDDB1CRBNKMT2AJMJD6 | |
| SCHEMBL20075849 | 0.77 | ALDH1A1 (0.51) | HAVCR2HSD17B10KMT2AADORA2AKDM4E | |
| SCHEMBL20076032 | 0.75 | NPC1 (0.45) | HAVCR2HSD17B10KMT2AKDM4EALDH1A1 | |
| SCHEMBL20076009 | 0.75 | ALDH1A1 (0.45) | HSD17B10KMT2AADORA2AKDM4EALDH1A1 | |
| SCHEMBL21681598 | 0.74 | KDM4E (0.33) | KDM5BHAVCR2TGFBR1HSD17B10KDM4E | |
| SCHEMBL20588719 | 0.74 | KDM4E (0.44) | HAVCR2HSD17B10KMT2AKDM4EALDH1A1 | |
| SCHEMBL20076013 | 0.73 | PIK3C3 (0.37) | KDM5BHAVCR2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL20076033 | 0.73 | TP53 (0.47) | KDM5BHAVCR2HSD17B10KMT2AKDM4E | |
| SCHEMBL20076038 | 0.73 | ADORA2A (0.47) | KDM5BHAVCR2HSD17B10ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | claimed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071282-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | KDM5B 2/4885HAVCR2 4388/4885TGFBR1 762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.