Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HAVCR2 | Q8TDQ0 | 3/20 | 0.34 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20075840 | 0.86 | KDM4E (0.41) | ALDH1A1LMNAKDM4EHPGDHSD17B10 | |
| SCHEMBL20076007 | 0.83 | USP2 (0.35) | ALDH1A1LMNAKDM4EHPGDHSD17B10 | |
| SCHEMBL20588719 | 0.83 | KDM4E (0.44) | ALDH1A1LMNAKDM4EHPGDHSD17B10 | |
| SCHEMBL20075885 | 0.77 | HAVCR2 (0.32) | ALDH1A1KDM4EHPGDHSD17B10HAVCR2 | |
| SCHEMBL20076035 | 0.75 | YTHDF2 (0.47) | ALDH1A1LMNAKDM4EHPGDHSD17B10 | |
| SCHEMBL20075837 | 0.74 | KDM4E (0.36) | ALDH1A1LMNAKDM4EHPGDHSD17B10 | |
| SCHEMBL20075834 | 0.74 | HAVCR2 (0.34) | ALDH1A1LMNAHPGDHSD17B10L3MBTL1 | |
| SCHEMBL12290303 | 0.73 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL20075893 | 0.73 | YTHDF2 (0.42) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL20075888 | 0.73 | YTHDF2 (0.42) | GAAPOLBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | claimed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071282-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | ALDH1A1 1410/4885LMNA 1985/4885KDM4E 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.