Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.47 |
| ▸ | YTHDF3 | Q7Z739 | 1/20 | 0.38 |
| ▸ | YTHDF1 | Q9BYJ9 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 4/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HAVCR2 | Q8TDQ0 | 3/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20075888 | 0.94 | YTHDF2 (0.42) | YTHDF2PLATNPY5RGAADAO | |
| SCHEMBL20075893 | 0.94 | YTHDF2 (0.42) | YTHDF2YTHDF3YTHDF1PLATRAD51 | |
| SCHEMBL20075886 | 0.93 | NPY5R (0.42) | YTHDF2PLATNPY5RGAADAO | |
| SCHEMBL20075889 | 0.90 | PIK3C3 (0.39) | YTHDF2PLATNPY5RDAOKDM5B | |
| SCHEMBL25037191 | 0.82 | YTHDF2 (0.44) | YTHDF2YTHDF3YTHDF1PLATRAD51 | |
| SCHEMBL20588719 | 0.77 | KDM4E (0.44) | ALDH1A1HSD17B10KDM4EHPGDCASP1 | |
| SCHEMBL31499730 | 0.77 | YTHDF2 (0.39) | YTHDF2YTHDF3YTHDF1PLATNPY5R | |
| SCHEMBL20075890 | 0.75 | NPY5R (0.38) | NPY5RALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL20076014 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EHPGDUSP2 | |
| SCHEMBL20075840 | 0.74 | KDM4E (0.41) | RAD51ALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | claimed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| WO-2018071282-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | YTHDF2 656/4885YTHDF3 636/4885YTHDF1 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.