YTHDF2

YTH domain-containing family protein 2 · Q9Y5A9 · YTHDF2 on Sugi Atlas →

469 patent compounds predicted against YTHDF2, 140 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL27388468 SCHEMBL27388468 0.39 4/20
SCHEMBL30898248 SCHEMBL30898248 0.51 3/20
SCHEMBL30898259 SCHEMBL30898259 0.44 3/20
SCHEMBL9414252 SCHEMBL9414252 1.00 2/20
SCHEMBL27387656 SCHEMBL27387656 1.00 2/20
SCHEMBL30898232 SCHEMBL30898232 1.00 2/20
SCHEMBL9414195 SCHEMBL9414195 0.83 2/20
SCHEMBL12612092 SCHEMBL12612092 0.81 2/20
SCHEMBL22239460 SCHEMBL22239460 0.81 2/20
SCHEMBL30898260 SCHEMBL30898260 0.78 2/20
SCHEMBL30898225 SCHEMBL30898225 0.73 2/20
SCHEMBL30898254 SCHEMBL30898254 0.72 2/20
SCHEMBL30898241 SCHEMBL30898241 0.62 2/20
SCHEMBL19583295 SCHEMBL19583295 0.59 2/20
SCHEMBL28197130 SCHEMBL28197130 0.59 2/20
SCHEMBL29316666 SCHEMBL29316666 0.59 2/20
SCHEMBL27768491 SCHEMBL27768491 0.58 2/20
SCHEMBL27937163 SCHEMBL27937163 0.56 2/20
SCHEMBL30898280 SCHEMBL30898280 0.56 2/20
SCHEMBL17112456 SCHEMBL17112456 0.53 2/20

Clinical trials — most relevant to YTHDF2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma PHASE2WITHDRAWN
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) nanUNKNOWN
Prognosis of METTL-14 in Endometrial Carcinoma nanNOT_YET_RECRUITING
Using the Epitranscriptome to Diagnose and Treat Gliomas nanRECRUITING
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study nanNOT_YET_RECRUITING
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
MEHMO Natural History and Biomarkers nanRECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Long Term Prediction of MASH-related HCC Risk by Proteomics nanNOT_YET_RECRUITING
Expression Pattern of HNRNPH1 and HNRNPK Genes in MPNs nanUNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Thermogenic Silencer Regulatory Factors in Humans nanACTIVE_NOT_RECRUITING
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks nanRECRUITING
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes nanUNKNOWN
Assessment of microRNAs Role in Familial Mediterranean Fever FMF Pathophysiology nanUNKNOWN
Genetic Risk Factors for Multi-system Inflammatory Syndrome in Children and Pediatric Post COVID Condition nanUNKNOWN
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT nanUNKNOWN
Target of Suv420h1/2 in Hepatocytes nanRECRUITING
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases nanNOT_YET_RECRUITING
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
Association Between the Change of the Genes With Hormones and Food Consumption of Obese nanCOMPLETED
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis nanCOMPLETED
Longitudinal Study of Neurogenetic Disorders nanRECRUITING
Precision Immunology to Determine the Immune Response in Patients With COVID-19 nanUNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
The Predictive Value of Guangzhou Panel for Recurrence in Early-stage Colorectal Cancer nanNOT_YET_RECRUITING
Search for Bovine miRNA Transference to Humans nanCOMPLETED
Effect of DNMT SNPs on DNA Methylation in Primary ITP nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a YTHDF2 binder may also engage these)

ProteinNameSimilarity
Q0VCZ3 1.000 Q0VCZ3 →
Q4R5D9 1.000 Q4R5D9 →
Q91YT7 1.000 Q91YT7 →
YTHDF1 YTH domain-containing family protein 1 0.997 landscape →
P59326 0.995 P59326 →
YTHDF3 YTH domain-containing family protein 3 0.993 landscape →
Q8BYK6 0.989 Q8BYK6 →
Q5RFL8 0.987 Q5RFL8 →
E7F1H9 0.977 E7F1H9 →
GATAD2B Transcriptional repressor p66-beta 0.965 landscape →
Q6PCR6 0.962 Q6PCR6 →
Q15032 0.962 Q15032 →
Q8BT14 0.961 Q8BT14 →
O95628 0.960 O95628 →
Q6GPM1 0.959 Q6GPM1 →
Q58A45 0.959 Q58A45 →
Q562A2 0.959 Q562A2 →
A0JNC2 0.959 A0JNC2 →
Q640Q5 0.958 Q640Q5 →
Q5U231 0.958 Q5U231 →
Q9P2N5 0.957 Q9P2N5 →
Q8VHR5 0.957 Q8VHR5 →
Q9UBL0 0.957 Q9UBL0 →
Q9Z1X4 0.956 Q9Z1X4 →
ZFR Zinc finger RNA-binding protein 0.956 landscape →
UBAP2L Ubiquitin-associated protein 2-like 0.956 landscape →
Q6ISB3 0.956 Q6ISB3 →
Q80TM6 0.955 Q80TM6 →
Q8CIE2 0.955 Q8CIE2 →
A1L1C7 0.955 A1L1C7 →