Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22906505 | 0.88 | KDM4E (0.40) | CA2ALDH1A1KDM4EKMT2ASCN1A | |
| SCHEMBL21725671 | 0.88 | KDM4E (0.40) | CA2ALDH1A1KDM4EKMT2ASCN1A | |
| SCHEMBL20324094 | 0.88 | KDM4E (0.40) | CA2ALDH1A1KDM4EKMT2ASCN1A | |
| SCHEMBL20075871 | 0.88 | KDM4E (0.40) | CA2ALDH1A1KDM4EKMT2ASCN1A | |
| SCHEMBL20075965 | 0.88 | KDM4E (0.40) | CA2ALDH1A1KDM4EKMT2ASCN1A | |
| SCHEMBL14707752 | 0.87 | ALDH1A1 (0.40) | CA2ALDH1A1KDM4EKMT2AHRH4 | |
| SCHEMBL20322537 | 0.84 | ALDH1A1 (0.44) | ALDH1A1EPHX2KDM4EHRH4HRH3 | |
| SCHEMBL23521014 | 0.83 | ALDH1A1 (0.33) | CA2ALDH1A1EPHX2KDM4EKMT2A | |
| SCHEMBL5910765 | 0.83 | ALDH1A1 (0.41) | CA2ALDH1A1EPHX2KDM4EKMT2A | |
| SCHEMBL18551477 | 0.82 | ALDH1A1 (0.44) | ALDH1A1EPHX2HRH4HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102067-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |