Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27038942 | 0.81 | ALDH1A1 (0.38) | TSHRGAAKDM4EALDH1A1HPGD | |
| SCHEMBL18551597 | 0.80 | GAA (0.37) | TSHRGAAKDM4EALDH1A1HPGD | |
| SCHEMBL20323711 | 0.80 | ALDH1A1 (0.36) | TSHRGAAKDM4EALDH1A1HPGD | |
| SCHEMBL13532058 | 0.77 | TSHR (0.43) | TSHRKDM4EL3MBTL1MAPTHTT | |
| SCHEMBL25636605 | 0.76 | ALDH1A1 (0.36) | TSHRGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19604970 | 0.75 | SLC6A2 (0.41) | TSHRKDM4EALDH1A1 | |
| SCHEMBL21669643 | 0.75 | SLC6A2 (0.30) | — | |
| SCHEMBL25479416 | 0.74 | TSHR (0.41) | TSHRKDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL20322433 | 0.74 | SLC6A2 (0.40) | TSHRKDM4EALDH1A1 | |
| SCHEMBL24500996 | 0.74 | SLC6A2 (0.40) | TSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102725-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |