Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22873401 | 0.96 | CRBN (0.53) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL22565718 | 0.87 | CRBN (0.50) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL23138921 | 0.85 | CRBN (0.47) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL26754973 | 0.84 | CRBN (0.43) | CRBNDDB1IKZF3TNFDRD2 | |
| SCHEMBL20046596 | 0.83 | CRBN (0.51) | CRBNDDB1IKZF3KDM4E | |
| SCHEMBL22047521 | 0.82 | CRBN (0.47) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL20233690 | 0.81 | CRBN (0.54) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL22873398 | 0.81 | CRBN (0.54) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL22565934 | 0.81 | CRBN (0.47) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL24735327 | 0.81 | CRBN (0.78) | CRBNDDB1IKZF3ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |