Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.35 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.35 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26754973 | 0.89 | CRBN (0.43) | CRBNDDB1TNFIKZF1IKZF2 | |
| SCHEMBL22873401 | 0.86 | CRBN (0.53) | CRBNDDB1TNFIKZF1IKZF2 | |
| SCHEMBL20046347 | 0.84 | CRBN (0.66) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL25059028 | 0.84 | CRBN (0.56) | CRBNDDB1IKZF1IKZF2IKZF3 | |
| SCHEMBL20076201 | 0.82 | CRBN (0.53) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL22565934 | 0.82 | CRBN (0.47) | CRBNDDB1TNFIKZF1IKZF2 | |
| SCHEMBL23138921 | 0.81 | CRBN (0.47) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL22565718 | 0.80 | CRBN (0.50) | CRBNDDB1TNFIKZF3ALDH1A1 | |
| SCHEMBL25133215 | 0.80 | CRBN (0.51) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL30985067 | 0.80 | CRBN (0.51) | CRBNDDB1TNFIKZF1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |