Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.61 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20077552 | 0.86 | GPR119 (0.49) | GPR119NR1H2NR1H3 | |
| SCHEMBL20077553 | 0.86 | GPR119 (0.49) | GPR119NR1H2NR1H3 | |
| SCHEMBL20077312 | 0.85 | GPR119 (0.60) | GPR119 | |
| SCHEMBL20077110 | 0.84 | GPR119 (0.55) | GPR119NR1H2NR1H3 | |
| SCHEMBL20060878 | 0.83 | GPR119 (0.67) | GPR119NR1H2NR1H3 | |
| SCHEMBL20077268 | 0.83 | GRIN2B (0.47) | GPR119 | |
| SCHEMBL30032228 | 0.82 | ALDH1A1 (0.60) | GPR119NR1H2NR1H3 | |
| SCHEMBL22894957 | 0.82 | GPR119 (0.46) | GPR119NR1H2NR1H3 | |
| SCHEMBL1575345 | 0.81 | GPR119 (0.65) | GPR119 | |
| SCHEMBL20077730 | 0.81 | GPR119 (0.56) | GPR119NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068296-A1 | PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| WO-2018071315-A2 | PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |