Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 8/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754533 | 0.89 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL27481713 | 0.87 | MAPK13 (0.59) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL4636974 | 0.84 | CDC25B (0.73) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL10780863 | 0.84 | MAPT (0.49) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL10778603 | 0.84 | MAPT (0.49) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL10777664 | 0.83 | GAA (0.51) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL10370948 | 0.81 | MAPT (0.53) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL5357396 | 0.80 | FABP4 (0.65) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL8442758 | 0.80 | MAPK13 (0.62) | MAPK13MAPK12MAPK11MAPK14GAA | |
| SCHEMBL4538101 | 0.80 | KMT2A (0.61) | MAPK13MAPK12MAPK11MAPK14GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208001-B2 | Process for preparing 1,4-dibenzodiazepines via Buchwald-Hartwig chemistry | UNIVERSIDADE DE EVORA (PT) | 2019-02-19 | — | — | US | disclosed |
| US-20180105502-A1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | UNIVERSIDADE DE EVORA (PT) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10208001-B2 | Process for preparing 1,4-dibenzodiazepines via Buchwald-Hartwig chemistry | HRH2, HRH4, HRH1 | MAPK13 1955/4885MAPK12 684/4885MAPK11 1563/4885 |
| US-20180105502-A1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | HRH2, HRH4, HRH1 | MAPK13 1955/4885MAPK12 684/4885MAPK11 1563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.