Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SELP | P16109 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26502774 | 0.89 | MEN1 (0.38) | ALDH1A1SMN1; SMN2GAAHPGDNPSR1 | |
| SCHEMBL26261230 | 0.84 | SMN1; SMN2 (0.35) | ALDH1A1SMN1; SMN2GAAHPGDNPSR1 | |
| SCHEMBL23594547 | 0.81 | SMN1; SMN2 (0.33) | ALDH1A1SMN1; SMN2GAAHPGDNPSR1 | |
| SCHEMBL23986624 | 0.81 | SMN1; SMN2 (0.33) | ALDH1A1SMN1; SMN2GAAHPGDNPSR1 | |
| SCHEMBL2120083 | 0.81 | KMT2A (0.52) | ALDH1A1TSHRSMN1; SMN2GAAHPGD | |
| SCHEMBL23331740 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TSHREPHX2SMN1; SMN2FAAH | |
| SCHEMBL25637025 | 0.80 | MEN1 (0.45) | ALDH1A1TSHRSMN1; SMN2GAAHPGD | |
| SCHEMBL23913185 | 0.79 | SMN1; SMN2 (0.34) | ALDH1A1SMN1; SMN2GAAHPGDNPSR1 | |
| SCHEMBL25637029 | 0.79 | KMT2A (0.51) | ALDH1A1SMN1; SMN2GAAHPGDNPSR1 | |
| SCHEMBL25145265 | 0.78 | GLP1R (0.48) | ALDH1A1MEN1KMT2AFAAHMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9950078-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2018-04-24 | — | — | US | disclosed |
| US-9950078-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2018-04-24 | — | — | US | disclosed |