Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PARG | Q86W56 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15541745 | 0.83 | SMN1; SMN2 (0.51) | ALDH1A1MAPK1SMN1; SMN2LMNATP53 | |
| SCHEMBL20078747 | 0.80 | ALDH1A1 (0.87) | ALDH1A1MAPK1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14419472 | 0.76 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNAKMT2ATDP1 | |
| SCHEMBL12970920 | 0.76 | ALDH1A1 (0.67) | ALDH1A1MAPK1SMN1; SMN2LMNAMAPT | |
| SCHEMBL12970919 | 0.76 | ALDH1A1 (0.67) | ALDH1A1MAPK1SMN1; SMN2LMNAMAPT | |
| SCHEMBL5466144 | 0.75 | LMNA (0.61) | ALDH1A1MAPK1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL1805024 | 0.75 | MAPK1 (0.55) | ALDH1A1MAPK1SMN1; SMN2KMT2ATDP1 | |
| SCHEMBL4959356 | 0.75 | MAPK1 (0.55) | MAPK1SMN1; SMN2LMNAKMT2ATDP1 | |
| SCHEMBL1805549 | 0.75 | MAPK1 (0.55) | MAPK1SMN1; SMN2MAPTKMT2AL3MBTL1 | |
| SCHEMBL31610152 | 0.74 | TP53 (0.56) | ALDH1A1MAPK1LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9949955-B2 | Triazolone compounds as mPGES-1 inhibitors | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-04-24 | — | — | US | disclosed |