Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16006573 | 0.77 | ALKBH5 (0.43) | TLR8DDB1CRBNGSK3BMEN1 | |
| SCHEMBL15995385 | 0.75 | DDB1 (0.38) | DDB1CRBNGSK3BMEN1KMT2A | |
| SCHEMBL9181361 | 0.75 | SCN9A (0.42) | DDB1CRBNGSK3B | |
| SCHEMBL17621334 | 0.74 | ENPP1 (0.40) | TTKLMNAHTT | |
| SCHEMBL30881908 | 0.73 | PDK2 (0.41) | ELANEDDB1CRBNGSK3BMEN1 | |
| SCHEMBL22886513 | 0.72 | GSK3B (0.36) | DDB1CRBNGSK3BGABRA1GABRB2 | |
| SCHEMBL16154737 | 0.72 | GSK3B (0.36) | DDB1CRBNGSK3BGABRA1GABRB2 | |
| SCHEMBL31330879 | 0.72 | TDP1 (0.47) | MEN1KMT2AGAAMAPT | |
| SCHEMBL15886675 | 0.72 | CCR4 (0.39) | TLR8KMT2AKEAP1LMNAMAPT | |
| SCHEMBL16158063 | 0.71 | HTT (0.34) | MEN1KMT2AGLALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951043-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |