Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25838728 | 0.76 | MEN1 (0.42) | MEN1KMT2ASIGMAR1GRIN2DGRIN3B | |
| SCHEMBL17519176 | 0.72 | SIGMAR1 (0.47) | MEN1KMT2ASIGMAR1GRIN2DGRIN3B | |
| SCHEMBL17424103 | 0.70 | MEN1 (0.46) | MEN1KMT2ASIGMAR1HSD17B10CARM1 | |
| SCHEMBL25575441 | 0.70 | MEN1 (0.46) | MEN1KMT2ASIGMAR1HSD17B10CARM1 | |
| SCHEMBL17519167 | 0.69 | SIGMAR1 (0.45) | MEN1KMT2ASIGMAR1GRIN2DGRIN3B | |
| SCHEMBL358919 | 0.69 | MEN1 (0.50) | MEN1KMT2ASIGMAR1HSD17B10MAPT | |
| SCHEMBL20357058 | 0.69 | MEN1 (0.50) | MEN1KMT2ASIGMAR1HSD17B10MAPT | |
| SCHEMBL6783279 | 0.69 | MEN1 (0.50) | MEN1KMT2ASIGMAR1HSD17B10MAPT | |
| SCHEMBL18205131 | 0.69 | MEN1 (0.50) | MEN1KMT2ASIGMAR1HSD17B10MAPT | |
| SCHEMBL15768017 | 0.69 | MEN1 (0.50) | MEN1KMT2ASIGMAR1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951048-B1 | Isoquinolin-3-yl carboxamides and preparation and use thereof | SAMUMED, LLC (US) | 2018-04-24 | — | — | US | disclosed |