Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368086 | 0.81 | CA12 (0.51) | NPC1POLBRAB9AMMP2MMP9 | |
| SCHEMBL7368088 | 0.81 | CA12 (0.51) | NPC1POLBRAB9AMMP2MMP9 | |
| SCHEMBL9997863 | 0.81 | MAPT (0.44) | NPC1POLBRAB9AKMT2ACACNA1B | |
| SCHEMBL7368082 | 0.81 | CA12 (0.51) | NPC1POLBRAB9AMMP2MMP9 | |
| SCHEMBL9997865 | 0.81 | MAPT (0.44) | NPC1POLBRAB9AKMT2ACACNA1B | |
| SCHEMBL9997355 | 0.80 | HSD11B1 (0.47) | POLBKMT2AMEN1MAPTLMNA | |
| SCHEMBL29034774 | 0.80 | CACNA1B (0.39) | NPC1POLBMMP1MMP2MMP9 | |
| SCHEMBL5756310 | 0.80 | CYP1A2 (0.47) | NPC1RAB9ACACNA1BALDH1A1MAPT | |
| SCHEMBL9997357 | 0.80 | HSD11B1 (0.47) | POLBKMT2AMEN1MAPTLMNA | |
| SCHEMBL9516822 | 0.80 | MAPT (0.45) | POLBMMP1MMP2MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751076-B1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | MEDIMMUNE LTD (GB) | 2018-04-25 | — | — | EP | disclosed |