Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.64 |
| ▸ | FLT3 | P36888 | 3/20 | 0.64 |
| ▸ | BLK | P51451 | 3/20 | 0.64 |
| ▸ | BTK | Q06187 | 7/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | ROS1 | P08922 | 1/20 | 0.53 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18294437 | 0.89 | EGFR (0.82) | EGFRFLT3BLKBTK | |
| SCHEMBL20080224 | 0.87 | EGFR (0.70) | EGFRFLT3BLKBTKALK | |
| SCHEMBL20080239 | 0.85 | EGFR (0.69) | EGFRFLT3BLKALKINSR | |
| SCHEMBL20080150 | 0.82 | EGFR (0.68) | EGFRFLT3BLKBTK | |
| SCHEMBL20080216 | 0.80 | EGFR (0.63) | EGFRFLT3BLKBTK | |
| SCHEMBL15752472 | 0.80 | EGFR (0.82) | EGFRFLT3BLKBTK | |
| SCHEMBL16680603 | 0.78 | EGFR (1.00) | EGFRFLT3BLKBTK | |
| SCHEMBL30192805 | 0.78 | EGFR (1.00) | EGFRFLT3BLKBTK | |
| SCHEMBL20080148 | 0.78 | FLT3 (0.63) | EGFRFLT3BLKBTK | |
| SCHEMBL15752437 | 0.78 | EGFR (0.83) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312180-A1 | USE OF PTERIDINONE DERIVATIVE SERVING AS EGFR INHIBITOR | East China University Of Science And Technology (CN) | 2018-04-25 | — | — | EP | disclosed |