Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.69 |
| ▸ | FLT3 | P36888 | 3/20 | 0.69 |
| ▸ | BLK | P51451 | 2/20 | 0.69 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18294441 | 0.90 | EGFR (0.86) | EGFRFLT3BLKJAK3 | |
| SCHEMBL29572941 | 0.90 | EGFR (0.86) | EGFRFLT3BLKJAK3 | |
| SCHEMBL20080224 | 0.88 | EGFR (0.70) | EGFRFLT3BLKJAK3ALK | |
| SCHEMBL20080201 | 0.85 | EGFR (0.64) | EGFRFLT3BLKALKINSR | |
| SCHEMBL20080150 | 0.85 | EGFR (0.68) | EGFRFLT3BLKJAK3 | |
| SCHEMBL16680603 | 0.81 | EGFR (1.00) | EGFRFLT3BLKJAK3 | |
| SCHEMBL30192805 | 0.81 | EGFR (1.00) | EGFRFLT3BLKJAK3 | |
| SCHEMBL20080148 | 0.80 | FLT3 (0.63) | EGFRFLT3BLKJAK3 | |
| SCHEMBL18294436 | 0.79 | EGFR (0.87) | EGFRFLT3BLKJAK3ALK | |
| SCHEMBL30353489 | 0.79 | EGFR (0.87) | EGFRFLT3BLKJAK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312180-A1 | USE OF PTERIDINONE DERIVATIVE SERVING AS EGFR INHIBITOR | East China University Of Science And Technology (CN) | 2018-04-25 | — | — | EP | disclosed |