Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11355255 | 0.91 | LMNA (0.40) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL4089525 | 0.91 | LMNA (0.40) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL4090160 | 0.91 | LMNA (0.40) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL11961399 | 0.90 | LMNA (0.40) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL11961400 | 0.90 | LMNA (0.40) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL4089514 | 0.88 | RAB9A (0.43) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL4087124 | 0.88 | RAB9A (0.43) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL3247283 | 0.88 | RAB9A (0.43) | LMNAGAAMEN1KMT2AMAPK14 | |
| SCHEMBL11357917 | 0.87 | MEN1 (0.44) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL17286674 | 0.87 | MEN1 (0.39) | LMNAGAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311813-A1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | Dart Neuroscience (Cayman) Ltd (KY) | 2018-04-25 | — | — | EP | disclosed |