Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 10/20 | 0.54 |
| ▸ | FAAH | O00519 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896911 | 0.89 | MGLL (0.46) | MGLLFAAHALDH1A1LMNAMAPT | |
| SCHEMBL10064443 | 0.80 | MGLL (0.59) | MGLLFAAHALDH1A1LMNAMAPT | |
| SCHEMBL15809670 | 0.75 | MGLL (0.60) | MGLLFAAHALDH1A1LMNAMAPT | |
| SCHEMBL17068245 | 0.75 | CYP3A4 (0.38) | NPSR1 | |
| SCHEMBL24740916 | 0.72 | MGLL (0.62) | MGLLFAAHALDH1A1LMNAMAPT | |
| SCHEMBL331378 | 0.72 | MGLL (0.88) | MGLLFAAHALDH1A1LMNAMAPT | |
| SCHEMBL155748 | 0.72 | MGLL (1.00) | MGLLFAAHALDH1A1LMNAMAPT | |
| SCHEMBL18927932 | 0.71 | — | — | |
| SCHEMBL29064616 | 0.71 | MGLL (0.67) | MGLLFAAHALDH1A1LMNAMAPT | |
| SCHEMBL5383694 | 0.70 | MGLL (1.00) | MGLLFAAHALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10646585-B2 | Hydrophilic linkers and ligand-drug conjugates thereof | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2020-05-12 | — | — | US | disclosed |
| US-10456479-B2 | Hydrophilic linkers and ligand-drug conjugates thereof | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2019-10-29 | — | — | US | disclosed |
| US-20190125894-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2019-05-02 | — | — | US | disclosed |
| US-20180110876-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2018-04-26 | — | — | US | disclosed |
| US-20180110876-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10456479-B2 | Hydrophilic linkers and ligand-drug conjugates thereof | CD44, SELPLG, EPCAM | MGLL 3210/4885FAAH 1664/4885ALDH1A1 1069/4885 |
| US-20180110876-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | CD44, HACD3, HACD2 | MGLL 3589/4885FAAH 1847/4885ALDH1A1 1285/4885 |
| US-20190125894-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | CD44, HACD3, HACD2 | MGLL 3589/4885FAAH 1847/4885ALDH1A1 1285/4885 |
| US-10646585-B2 | Hydrophilic linkers and ligand-drug conjugates thereof | CD44, SELPLG, EPCAM | MGLL 3210/4885FAAH 1664/4885ALDH1A1 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.