Sugi Predict

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SCHEMBL20087404

SCHEMBL20087404

CC(C)(C)OC(=O)CN(CCN1C(=O)C=CC1=O)C(N)=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AKT1 P31749 2/20 0.36
▸ ALDH1A1 P00352 3/20 0.36
▸ BLM P54132 2/20 0.36
▸ HPGD P15428 2/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ WRN Q14191 1/20 0.36
▸ HIF1A Q16665 1/20 0.36
▸ GSK3A P49840 1/20 0.35
▸ GSK3B P49841 1/20 0.35
▸ MGLL Q99685 6/20 0.33
▸ FAAH O00519 3/20 0.33
▸ LMNA P02545 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ NPSR1 Q6W5P4 2/20 0.33
▸ GMNN O75496 1/20 0.33
▸ THPO P40225 1/20 0.33
▸ PMP22 Q01453 1/20 0.33
▸ PTGS1 P23219 7/20 0.32
▸ PTGS2 P35354 7/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20091650 0.85 ALDH1A1 (0.38) ALDH1A1BLMHPGDCYP1A2CYP2C19
SCHEMBL20365060 0.78 AKT1 (0.36) AKT1ALDH1A1BLMHPGDCYP1A2
SCHEMBL20087389 0.78 AKT1 (0.36) AKT1ALDH1A1BLMHPGDCYP1A2
SCHEMBL20087397 0.78 PTGS1 (0.45) ALDH1A1BLMHPGDCYP1A2CYP2C19
SCHEMBL20087394 0.77 AKT1 (0.36) AKT1ALDH1A1BLMHPGDCYP1A2
SCHEMBL20087398 0.76 ALDH1A1 (0.31) ALDH1A1BLMHPGDCYP1A2CYP2C19
SCHEMBL14984829 0.75 ALDH1A1 (0.44) AKT1ALDH1A1BLMHPGDCYP1A2
SCHEMBL16097062 0.73 PTGS1 (0.44) AKT1ALDH1A1BLMHPGDCYP1A2
SCHEMBL30143463 0.71 AKT1 (0.50) AKT1ALDH1A1BLMHPGDCYP1A2
SCHEMBL17222828 0.71 AKT1 (0.39) AKT1ALDH1A1BLMHPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3912982-A1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF Hangzhou Dac Biotech Co., Ltd (CN) 2021-11-24 — — EP disclosed
EP-3271329-B1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF HANGZHOU DAC BIOTECH CO LTD (CN) 2021-08-18 — — EP disclosed
US-10646585-B2 Hydrophilic linkers and ligand-drug conjugates thereof HANGZHOU DAC BIOTECH CO., LTD. (CN) 2020-05-12 — — US disclosed
US-20190125894-A1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-05-02 — — US disclosed
US-20180110876-A1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF HANGZHOU DAC BIOTECH CO., LTD. (CN) 2018-04-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180110876-A1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF CD44, HACD3, HACD2 AKT1 4142/4885ALDH1A1 1285/4885BLM 3928/4885
US-20190125894-A1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF CD44, HACD3, HACD2 AKT1 4142/4885ALDH1A1 1285/4885BLM 3928/4885
US-10646585-B2 Hydrophilic linkers and ligand-drug conjugates thereof CD44, SELPLG, EPCAM AKT1 3890/4885ALDH1A1 1069/4885BLM 3689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.