Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016473 | 0.80 | GRM5 (0.61) | GRM5 | |
| SCHEMBL2014000 | 0.76 | GRM5 (1.00) | GRM5GRM3 | |
| SCHEMBL2012693 | 0.74 | GRM5 (0.57) | GRM5GRM3 | |
| SCHEMBL2013894 | 0.71 | GRM5 (0.73) | GRM5PTGS1PTGS2 | |
| SCHEMBL12307649 | 0.68 | RECQL (0.50) | GRM5HRH3 | |
| SCHEMBL2011738 | 0.68 | GRM5 (0.49) | GRM5 | |
| SCHEMBL2012544 | 0.68 | GRM5 (0.83) | GRM5PTGS1PTGS2GRM3 | |
| SCHEMBL22633634 | 0.67 | HRH4 (0.48) | GRM5HRH3 | |
| SCHEMBL2013990 | 0.67 | GRM5 (0.75) | GRM5 | |
| SCHEMBL22961628 | 0.67 | GRM5 (0.51) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513117-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | Janssen Pharmaceutica, N.V. (BE) | 2012-10-24 | — | — | EP | claimed |
| WO-2011073339-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | WO | claimed |