Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016473 | 0.94 | GRM5 (0.61) | GRM5NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL156464 | 0.81 | GRM5 (0.52) | GRM5 | |
| SCHEMBL2011738 | 0.81 | GRM5 (0.49) | GRM5 | |
| SCHEMBL158425 | 0.78 | GRM5 (0.53) | GRM5NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL2013895 | 0.77 | GRM5 (0.88) | GRM5GRM3 | |
| SCHEMBL2009451 | 0.74 | GRM5 (0.61) | GRM5GRM3 | |
| SCHEMBL2012403 | 0.72 | GRM5 (1.00) | GRM5 | |
| SCHEMBL157209 | 0.71 | GRM5 (0.57) | GRM5 | |
| SCHEMBL155658 | 0.70 | GRM5 (0.53) | GRM5 | |
| SCHEMBL158128 | 0.70 | GRM5 (0.48) | GRM5NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073339-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | WO | disclosed |