Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13567284 | 0.81 | RXFP1 (0.40) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL19315826 | 0.81 | ALDH1A1 (0.44) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL23994365 | 0.79 | LMNA (0.46) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL6448942 | 0.78 | ALDH1A1 (0.38) | TSHRALDH1A1LMNACA2HSD17B10 | |
| SCHEMBL27413217 | 0.75 | TSHR (0.52) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL23346590 | 0.75 | EPHX1 (0.37) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL27390051 | 0.75 | EPHX1 (0.46) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL745482 | 0.74 | ALDH1A1 (0.54) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL16314492 | 0.72 | ALDH1A1 (0.39) | TSHRALDH1A1EPHX1LMNAMEN1 | |
| SCHEMBL3071611 | 0.72 | CRBN (0.43) | TSHRALDH1A1EPHX1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075842-A1 | CONDENSED BENZODIAZEPINE DERIVATIVES AND CONJUGATES MADE THEREFROM | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-26 | — | — | WO | disclosed |