Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294885 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2L3MBTL1KMT2AGAAHSD17B10 | |
| SCHEMBL9713054 | 0.85 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1KMT2AGAAHSD17B10 | |
| SCHEMBL18893269 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1KMT2AGAAHSD17B10 | |
| SCHEMBL13753759 | 0.83 | RAB9A (0.60) | SMN1; SMN2KMT2AGAAHSD17B10MEN1 | |
| SCHEMBL28145662 | 0.83 | KCNK3 (0.57) | SMN1; SMN2L3MBTL1KMT2AGAAMEN1 | |
| SCHEMBL19426831 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1KMT2AGAAHSD17B10 | |
| SCHEMBL21792030 | 0.82 | ALDH1A1 (0.59) | SMN1; SMN2L3MBTL1KMT2AGAAHSD17B10 | |
| SCHEMBL12852589 | 0.82 | GAA (0.76) | SMN1; SMN2KMT2AGAAHSD17B10MEN1 | |
| SCHEMBL12852621 | 0.82 | NAMPT (0.47) | SMN1; SMN2L3MBTL1KMT2AGAAHSD17B10 | |
| SCHEMBL2299458 | 0.82 | HDAC8 (0.63) | SMN1; SMN2L3MBTL1KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075600-A1 | TARGETED DELIVERY OF NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY INHIBITORS | SEATTLE GENETICS, INC. (US) | 2018-04-26 | — | — | WO | disclosed |