Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CASR | P41180 | 3/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20063477 | 0.88 | SCN9A (0.50) | NOTUMSCN9AALDH1A1CASRHTR3E | |
| SCHEMBL21904711 | 0.87 | CASR (0.51) | NOTUMSCN9AALDH1A1CASRHTR3E | |
| SCHEMBL20063498 | 0.87 | CASR (0.51) | NOTUMSCN9AALDH1A1CASRHTR3E | |
| SCHEMBL20063904 | 0.83 | NOTUM (0.57) | NOTUMSCN9AALDH1A1CASRHTR3E | |
| SCHEMBL20063903 | 0.81 | NOTUM (0.51) | NOTUMSCN9ACASRMAPTTHRB | |
| SCHEMBL11544167 | 0.81 | NOTUM (0.57) | NOTUMALDH1A1CASRHTR3EHTR3B | |
| SCHEMBL20095504 | 0.78 | NOTUM (0.49) | NOTUMSCN9AALDH1A1CASRHTR3E | |
| SCHEMBL21838591 | 0.78 | NOTUM (0.57) | NOTUMSCN9AALDH1A1MAPTACACB | |
| SCHEMBL17754046 | 0.78 | ALDH1A1 (0.59) | NOTUMALDH1A1HTR3EHTR3BHTR1D | |
| SCHEMBL20096221 | 0.76 | NOTUM (0.54) | NOTUMALDH1A1CASRHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |