Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 9/20 | 0.36 |
| ▸ | HTR7 | P34969 | 9/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095688 | 1.00 | HTR2C (0.39) | HTR2CHTR2AHTR2BHRH3HTR1A | |
| SCHEMBL21311610 | 0.82 | NISCH (0.40) | HTR1AHTR7CHRM3 | |
| SCHEMBL21311611 | 0.82 | NISCH (0.40) | HTR1AHTR7CHRM3 | |
| SCHEMBL20096267 | 0.81 | HTR1A (0.53) | HTR2CHTR2AHTR2BHRH3HTR1A | |
| SCHEMBL20096018 | 0.81 | HTR1A (0.53) | HTR2CHTR2AHTR2BHRH3HTR1A | |
| SCHEMBL20095952 | 0.81 | HTR2A (0.39) | HTR2CHTR2AHTR2BHRH3HTR1A | |
| SCHEMBL20095951 | 0.81 | HTR2A (0.39) | HTR2CHTR2AHTR2BHRH3HTR1A | |
| SCHEMBL20096104 | 0.79 | HTR1A (0.55) | HTR2CHTR2AHTR2BHRH3HTR1A | |
| SCHEMBL21311618 | 0.73 | USP30 (0.41) | HTR1ACTSS | |
| SCHEMBL21312006 | 0.72 | ERCC1 (0.39) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |