Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 8/20 | 0.37 |
| ▸ | HTR7 | P34969 | 8/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095951 | 1.00 | HTR2A (0.39) | HTR2AHTR2CHTR2BHRH3HTR1A | |
| SCHEMBL21311611 | 0.84 | NISCH (0.40) | HTR1AHTR7CHRNB4CHRNA3SLC6A4 | |
| SCHEMBL21311610 | 0.84 | NISCH (0.40) | HTR1AHTR7CHRNB4CHRNA3SLC6A4 | |
| SCHEMBL20096267 | 0.82 | HTR1A (0.53) | HTR2AHTR2CHTR2BHRH3HTR1A | |
| SCHEMBL20096018 | 0.82 | HTR1A (0.53) | HTR2AHTR2CHTR2BHRH3HTR1A | |
| SCHEMBL20095688 | 0.81 | HTR2C (0.39) | HTR2AHTR2CHTR2BHRH3HTR1A | |
| SCHEMBL20095694 | 0.81 | HTR2C (0.39) | HTR2AHTR2CHTR2BHRH3HTR1A | |
| SCHEMBL21312016 | 0.80 | RAB9A (0.40) | HRH3GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL20096104 | 0.80 | HTR1A (0.55) | HTR2AHTR2CHTR2BHRH3HTR1A | |
| SCHEMBL5198483 | 0.77 | SLC6A4 (0.53) | HTR2AHTR2CHTR2BHRH3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |