Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.55 |
| ▸ | DRD3 | P35462 | 8/20 | 0.55 |
| ▸ | DRD1 | P21728 | 5/20 | 0.55 |
| ▸ | DRD4 | P21917 | 5/20 | 0.55 |
| ▸ | DRD5 | P21918 | 5/20 | 0.55 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20096107 | 1.00 | DRD2 (0.55) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL20095930 | 1.00 | DRD2 (0.55) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL21312203 | 0.84 | DRD2 (0.39) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL4379176 | 0.82 | DRD3 (0.67) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL20096106 | 0.82 | MGLL (0.42) | SIGMAR1 | |
| SCHEMBL20095848 | 0.82 | MGLL (0.42) | SIGMAR1 | |
| SCHEMBL20095849 | 0.82 | MGLL (0.42) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7994687 | 0.81 | DRD3 (0.65) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL21311808 | 0.78 | HTR2C (0.50) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL21311628 | 0.78 | HTR2C (0.50) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |