Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20063805 | 1.00 | BTK (0.40) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL1992927 | 0.89 | NFKB1 (0.42) | BTKNFKB1NFKB2RELACTSK | |
| SCHEMBL15420557 | 0.87 | BTK (0.47) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL15420433 | 0.87 | BTK (0.47) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL20959100 | 0.87 | BTK (0.47) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL15420199 | 0.87 | BTK (0.47) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL12989321 | 0.87 | BTK (0.47) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL30565067 | 0.87 | BTK (0.47) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL15420108 | 0.84 | RORC (0.36) | BTKRORCNFKB1NFKB2RELA | |
| SCHEMBL26253780 | 0.84 | RORC (0.36) | BTKRORCNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |