SCHEMBL20095971

SCHEMBL20095971

CN(C)C1CN(C(=O)C2CC2)C1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 10/20 0.50
CHRNA3 P32297 10/20 0.50
CHRNA4 P43681 10/20 0.50
CHRNB3 Q05901 5/20 0.50
CHRNA6 Q15825 5/20 0.50
CHRNB4 P30926 5/20 0.48
CHRNA7 P36544 5/20 0.48
HSD11B1 P28845 4/20 0.45
HPGD P15428 1/20 0.45
MAPT P10636 1/20 0.43
HSD11B2 P80365 1/20 0.42
HTT P42858 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24995209 0.83 CHRNB2 (0.38) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL16254567 0.82 CHRNB2 (0.46) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL20063343 0.80 CHRNB2 (0.44) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL20095807 0.79 HSD11B1 (0.52) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL18595964 0.79 CHRNB2 (0.43) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL26421320 0.79 HRH3 (0.42) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL16252579 0.79 CHRNB2 (0.43) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL26419253 0.79 ATM (0.37) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL26024704 0.78 CHRNB2 (0.46) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL13621127 0.76 HTT (0.44) HPGDHTTALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018072602-A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2018-04-26 WO disclosed