Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 6/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | QPCTL | Q9NXS2 | 3/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21117234 | 0.88 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2QPCTMMP12 | |
| SCHEMBL24420726 | 0.80 | SMN1; SMN2 (0.51) | NPC1RAB9ASCN4ASMN1; SMN2AKR1B1 | |
| SCHEMBL19966707 | 0.80 | SMN1; SMN2 (0.51) | NPC1RAB9ASCN4ASMN1; SMN2AKR1B1 | |
| SCHEMBL19308856 | 0.80 | NPC1 (0.48) | NPC1RAB9ASCN4ASMN1; SMN2AKR1B1 | |
| SCHEMBL19966718 | 0.78 | RAB9A (0.49) | NPC1RAB9ASCN4ASMN1; SMN2AKR1B1 | |
| SCHEMBL8013060 | 0.78 | PRKCI (0.53) | RAB9ASMN1; SMN2QPCTMMP12PRKCI | |
| SCHEMBL26339590 | 0.76 | NPC1 (0.44) | NPC1RAB9ASCN4ASMN1; SMN2AKR1B1 | |
| SCHEMBL19308817 | 0.75 | KDM4E (0.37) | RAB9AQPCTMMP12PRKCIHTT | |
| SCHEMBL19966819 | 0.75 | NPC1 (0.43) | NPC1RAB9ASCN4ASMN1; SMN2AKR1B1 | |
| SCHEMBL19954923 | 0.73 | NPC1 (0.40) | NPC1RAB9ASCN4ASMN1; SMN2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957281-B2 | Benzodiazepine derivatives as RSV inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-01 | — | — | US | disclosed |