Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308856 | 0.93 | NPC1 (0.48) | NPC1SCN4ARAB9ASMN1; SMN2PFKFB3 | |
| SCHEMBL24840305 | 0.89 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2PFKFB3NTRK1 | |
| SCHEMBL20004008 | 0.83 | RAB9A (0.47) | NPC1SCN4ARAB9ASMN1; SMN2PFKFB3 | |
| SCHEMBL26342576 | 0.81 | OGA (0.36) | NPC1SCN4ARAB9ASMN1; SMN2HDAC6 | |
| SCHEMBL277372 | 0.79 | NPC1 (0.50) | NPC1SCN4ARAB9ASMN1; SMN2PFKFB3 | |
| SCHEMBL21871342 | 0.78 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2NTRK1NTRK2 | |
| SCHEMBL18898373 | 0.78 | HDAC6 (0.37) | NPC1SCN4ARAB9ASMN1; SMN2HDAC6 | |
| SCHEMBL19966718 | 0.77 | RAB9A (0.49) | NPC1SCN4ARAB9ASMN1; SMN2HDAC6 | |
| SCHEMBL24420726 | 0.76 | SMN1; SMN2 (0.51) | NPC1SCN4ARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19966707 | 0.76 | SMN1; SMN2 (0.51) | NPC1SCN4ARAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382907-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN INC. | 2023-11-30 | — | — | US | disclosed |
| US-11241450-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | TUFTS UNIVERSITY (US) | 2022-02-08 | — | — | US | disclosed |
| WO-2021194959-A1 | TREATMENT OF EYE DISORDERS WITH URIDINE PHOSPHATE DERIVATIVES | GLIAGUARD, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
| US-11124536-B2 | Uridine nucleoside derivatives, compositions and methods of use | TUFTS UNIVERSITY (US) | 2021-09-21 | — | — | US | disclosed |
| US-11072627-B2 | Uridine diphosphate derivatives, compositions and methods for treating neurodegenerative disorders | TUFTS UNIVERSITY (US) | 2021-07-27 | — | — | US | disclosed |
| US-20210069226-A1 | URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND USES THEREOF | TUFTS UNIVERSITY (US) | 2021-03-11 | — | — | US | disclosed |
| US-20200399302-A1 | URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | TUFTS UNIVERSITY | 2020-12-24 | — | — | US | disclosed |
| US-20190309009-A1 | URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS | TUFTS UNIVERSITY | 2019-10-10 | — | — | US | disclosed |
| US-10392377-B2 | Substituted 2-imino-1,3-thiazolidin-4-ones as N-arachidonoylethanolamine cellular uptake inhibitors | UNIVERSITAT BERN (CH) | 2019-08-27 | — | — | US | disclosed |
| US-20190119265-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | UNIVERSITAT BERN (CH) | 2019-04-25 | — | — | US | disclosed |
| US-20180085386-A1 | URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | TUFTS UNIVERSITY | 2018-03-29 | — | — | US | disclosed |
| US-9913855-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | TUFTS UNIVERSITY (US) | 2018-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124536-B2 | Uridine nucleoside derivatives, compositions and methods of use | P2RY6, UPP1, UMPS | NPC1 1587/4885SCN4A 2514/4885RAB9A 1050/4885 |
| US-20190309009-A1 | URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS | P2RY6, P2RX6, P2RY1 | NPC1 835/4885SCN4A 2014/4885RAB9A 1234/4885 |
| US-20200399302-A1 | URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | P2RY6, UPP1, UMPS | NPC1 1587/4885SCN4A 2514/4885RAB9A 1050/4885 |
| US-20180085386-A1 | URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | P2RY6, UPP1, UMPS | NPC1 1808/4885SCN4A 2470/4885RAB9A 965/4885 |
| US-20230382907-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ABL1, ABL2, BCR | NPC1 4143/4885SCN4A 3844/4885RAB9A 1191/4885 |
| US-10392377-B2 | Substituted 2-imino-1,3-thiazolidin-4-ones as N-arachidonoylethanolamine cellular uptake inhibitors | CNR2, CNR1, GPR18 | NPC1 15/4885SCN4A 2611/4885RAB9A 2866/4885 |
| US-20190119265-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | GRIN2B, IL1B, GRIA4 | NPC1 1319/4885SCN4A 1528/4885RAB9A 3087/4885 |
| US-20210069226-A1 | URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND USES THEREOF | UMPS, UPP1, UGDH | NPC1 1110/4885SCN4A 2734/4885RAB9A 246/4885 |
| US-11241450-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | UMPS, UPP1, UGDH | NPC1 1110/4885SCN4A 2734/4885RAB9A 246/4885 |
| US-11072627-B2 | Uridine diphosphate derivatives, compositions and methods for treating neurodegenerative disorders | P2RY6, P2RX6, P2RY1 | NPC1 584/4885SCN4A 1745/4885RAB9A 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.