Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 11/20 | 0.53 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010322 | 0.92 | GYS1 (0.48) | GYS1PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL2012650 | 0.81 | GYS1 (0.53) | GYS1PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL2011587 | 0.81 | GYS1 (0.75) | GYS1PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL2009949 | 0.80 | GYS1 (0.53) | GYS1PPARAMAOBFFAR1 | |
| SCHEMBL2012329 | 0.80 | GYS1 (0.52) | GYS1PPARA | |
| SCHEMBL2009810 | 0.78 | GYS1 (0.69) | GYS1PPARAMAOBF10FFAR1 | |
| SCHEMBL2013796 | 0.77 | GYS1 (0.59) | GYS1PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL2010695 | 0.75 | GYS1 (0.52) | GYS1PPARAPPARGMAOB | |
| SCHEMBL2010321 | 0.73 | GYS1 (0.46) | GYS1PPARAMAOBFFAR1 | |
| SCHEMBL2010369 | 0.71 | GYS1 (0.82) | GYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011067266-A1 | CARBOXYLIC ACID ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-09 | — | — | WO | claimed |
| WO-2011067266-A1 | CARBOXYLIC ACID ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-09 | — | — | WO | disclosed |