SCHEMBL20099862

SCHEMBL20099862

Cc1ccc(CCCCO)nc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 2/20 0.42
CCR1 P32246 1/20 0.40
CCR5 P51681 1/20 0.40
CCR8 P51685 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
ADRA2A P08913 3/20 0.39
ADRA2B P18089 3/20 0.39
ADRA2C P18825 3/20 0.39
PLAU P00749 1/20 0.39
NOS3 P29474 1/20 0.38
NOS2 P35228 1/20 0.38
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
DAO P14920 1/20 0.35
RAB9A P51151 2/20 0.35
MAPT P10636 1/20 0.35
NPC1 O15118 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ADORA2A P29274 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8665678 0.94 CCR1 (0.41) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL1683332 0.86 CCR1 (0.44) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL8852051 0.82 KCNH2 (0.47) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL18682734 0.81 CCR1 (0.52) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL18626629 0.81 KCNH2 (0.50) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL10703321 0.81 HRH1 (0.50) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL19222360 0.81 KCNH2 (0.50) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL20180121 0.81 KCNH2 (0.50) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL9921222 0.80 ALDH1A1 (0.44) PDE10ACCR1CCR5CCR8HDAC6
SCHEMBL1849855 0.79 ADRA2A (0.42) PDE10ACCR1CCR5CCR8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023192178-A1 PROCESS FOR PREPARING ((1S,2S)-2-(5-METHYLPYRIDIN-2-YL)CYCLOPROPYL)-METHANOL MERCK SHARP & DOHME LLC (US) 2023-10-05 WO disclosed
WO-2023184486-A1 PROCESS FOR PREPARING ( (1S, 2S) -2- (5-METHYLPYRIDIN-2-YL) CYCLOPROPYL) -METHANOL MERCK SHARP & DOHME LLC (US) 2023-10-05 WO disclosed
EP-3315492-B1 PYRAZOLE DERIVATIVE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF KISSEI PHARMACEUTICAL (JP) 2020-09-16 EP disclosed
EP-3315492-A1 PYRAZOLE DERIVATIVE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Kissei Pharmaceutical Co., Ltd. (JP) 2018-05-02 EP disclosed