Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333047 | 0.76 | HRH1 (0.50) | LMNAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL20099950 | 0.76 | MAPT (0.39) | LMNAKCNA5CYP1A2AGTR1MEN1 | |
| SCHEMBL22421032 | 0.76 | HRH1 (0.50) | LMNAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL22420979 | 0.72 | TSHR (0.40) | LMNACYP1A2AGTR1TSHRMAPK1 | |
| SCHEMBL20099906 | 0.72 | TSHR (0.40) | LMNACYP1A2AGTR1TSHRMAPK1 | |
| SCHEMBL11883339 | 0.71 | AKR1B1 (0.34) | NAAA | |
| SCHEMBL4276100 | 0.71 | — | — | |
| SCHEMBL10203044 | 0.70 | AAK1 (0.36) | ALDH1A1CYP1A2KDM4ENAAATSHR | |
| SCHEMBL3298714 | 0.68 | KDM4E (0.35) | THRBKCNJ5KCNJ3ALDH1A1CYP1A2 | |
| SCHEMBL6164386 | 0.68 | NAAA (0.38) | LMNAKCNA5ALDH1A1KDM4ENAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3315492-A1 | PYRAZOLE DERIVATIVE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2018-05-02 | — | — | EP | disclosed |