Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631602 | 1.00 | KMT2A (0.60) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL2033590 | 0.94 | KMT2A (0.55) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL2010908 | 0.91 | KMT2A (0.52) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL12631358 | 0.91 | KMT2A (0.52) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL2033680 | 0.90 | ALDH1A1 (0.57) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL12631366 | 0.90 | ALDH1A1 (0.57) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL12629091 | 0.90 | CYP2C19 (0.61) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL2048329 | 0.90 | CYP2C19 (0.61) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL12631678 | 0.87 | ALDH1A1 (0.46) | KMT2AMEN1CYP2C19ALDH1A1TSHR | |
| SCHEMBL12632371 | 0.87 | ALDH1A1 (0.46) | KMT2AMEN1CYP2C19ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073277-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS Kv1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |