Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 5/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 9/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20100828 | 0.88 | COMT (0.72) | COMTFTOMAOAMAOBMEN1 | |
| SCHEMBL29493647 | 0.88 | COMT (0.72) | COMTFTOMAOAMAOBMEN1 | |
| SCHEMBL20100827 | 0.87 | FTO (0.59) | COMTFTOMAOAMAOBMEN1 | |
| SCHEMBL20100835 | 0.84 | COMT (0.78) | COMTFTOMAOAMAOBMEN1 | |
| SCHEMBL15294424 | 0.78 | TTR (0.56) | COMTFTOMAOAMAOBMEN1 | |
| SCHEMBL20100837 | 0.78 | FTO (0.78) | COMTFTOMAOAMAOBMEN1 | |
| SCHEMBL28715873 | 0.74 | FTO (0.76) | COMTFTOMEN1ALDH1A1MAPT | |
| SCHEMBL29493650 | 0.74 | FTO (0.76) | COMTFTOMEN1ALDH1A1MAPT | |
| SCHEMBL20100854 | 0.74 | COMT (0.72) | COMTFTOMEN1ALDH1A1MAPT | |
| SCHEMBL20100853 | 0.74 | FTO (0.76) | COMTFTOMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238127-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-08-05 | — | — | US | disclosed |
| US-10988440-B2 | FTO inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-27 | — | — | US | disclosed |
| EP-3303283-B1 | FTO INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-04-21 | — | — | EP | disclosed |
| US-10980766-B2 | Entacapone-related compounds to treat macular degeneration | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-20 | — | — | US | disclosed |
| US-20200148628-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-05-14 | — | — | US | disclosed |
| US-20190183842-A1 | Entacapone-related Compounds to Treat Macular Degeneration | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-06-20 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980766-B2 | Entacapone-related compounds to treat macular degeneration | PDE6C, PDE6D, MC3R | COMT 469/4885FTO 2501/4885MAOA 1164/4885 |
| US-20190183842-A1 | Entacapone-related Compounds to Treat Macular Degeneration | PDE6C, PDE6D, MC3R | COMT 469/4885FTO 2501/4885MAOA 1164/4885 |
| US-20180118665-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885MAOA 162/4885 |
| US-20210238127-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885MAOA 162/4885 |
| US-20200148628-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885MAOA 162/4885 |
| US-10988440-B2 | FTO inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885MAOA 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.